Masanori Watanabe Selected Research

Enteropeptidase

1/2022	Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity.
1/2021	Enteropeptidase inhibition improves kidney function in a rat model of diabetic kidney disease.
1/2021	Enteropeptidase inhibitor SCO-792 effectively prevents kidney function decline and fibrosis in a rat model of chronic kidney disease.
1/2021	Enteropeptidase inhibition improves obesity by modulating gut microbiota composition and enterobacterial metabolites in diet-induced obese mice.
10/2019	SCO-792, an enteropeptidase inhibitor, improves disease status of diabetes and obesity in mice.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Masanori Watanabe Research Topics

Disease

9	Neoplasms (Cancer) 01/2017 - 08/2002
8	Obesity 01/2022 - 06/2014
6	Stomach Neoplasms (Stomach Cancer) 01/2022 - 02/2006
5	Pain (Aches) 01/2015 - 01/2004
4	Type 2 Diabetes Mellitus (MODY) 02/2022 - 01/2017
4	Inflammation (Inflammations) 01/2022 - 06/2014
4	Fibrosis (Cirrhosis) 11/2021 - 10/2020
4	Body Weight (Weight, Body) 10/2020 - 01/2019
4	Postoperative Pain 01/2017 - 01/2004
3	Chronic Renal Insufficiency 11/2021 - 06/2014
3	Hemorrhage 09/2021 - 07/2003
3	Carcinoma (Carcinomatosis) 01/2017 - 06/2007
3	Infections 01/2017 - 11/2005
2	Hernia (Hernias) 01/2022 - 04/2019
2	Non-alcoholic Fatty Liver Disease 11/2021 - 10/2020
2	Hypoglycemia (Reactive Hypoglycemia) 10/2021 - 11/2017
2	Insulin Resistance 01/2021 - 10/2019
2	Sepsis (Septicemia) 01/2020 - 01/2017
2	Flushing 12/2019 - 01/2018
2	Inguinal Hernia (Direct Inguinal Hernia) 04/2019 - 02/2008
2	Wounds and Injuries (Trauma) 01/2017 - 01/2015
2	Pneumoperitoneum 10/2009 - 01/2004
2	Colorectal Neoplasms (Colorectal Cancer) 02/2005 - 08/2002
1	Hepatocellular Carcinoma (Hepatoma) 02/2022
1	Protein-Losing Enteropathies (Protein-Losing Enteropathy) 01/2022
1	Lymphoma (Lymphomas) 01/2022
1	Internal Hernia 01/2022
1	Hyperplasia 01/2022
1	Hypertrophy 11/2021
1	Hyperglycemia 10/2021
1	Diverticular Diseases 09/2021
1	Diabetic Nephropathies (Diabetic Nephropathy) 01/2021
1	Chronic Disease (Chronic Diseases) 01/2021
1	Albuminuria 01/2021
1	Edema (Dropsy) 12/2019

Drug/Important Bio-Agent (IBA)

7	Glucose (Dextrose)FDA LinkGeneric 02/2022 - 06/2017
5	EnteropeptidaseIBA 01/2022 - 10/2019
4	Proteins (Proteins, Gene)FDA Link 01/2022 - 08/2002
4	SCO-267IBA 10/2021 - 01/2019
4	N- (((3S)- 6- ((4- carbamimidamidobenzoyl)oxy)- 2,3- dihydro- 1- benzofuran- 3- yl)acetyl)- L- aspartic acid hydrateIBA 01/2021 - 10/2019
3	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 02/2007
3	Pharmaceutical PreparationsIBA 01/2021 - 01/2017
3	Messenger RNA (mRNA)IBA 10/2020 - 08/2002
2	Hormones (Hormone)IBA 10/2021 - 01/2019
2	Therapeutic UsesIBA 01/2021 - 01/2021
2	LipidsIBA 10/2019 - 01/2018
2	Insulin (Novolin)FDA Link 06/2017 - 06/2007
2	Analgesics (Analgesic Drugs)IBA 01/2015 - 03/2005
2	Fentanyl (Sublimaze)FDA LinkGeneric 09/2008 - 03/2005
2	keratinocyte growth factor receptorIBA 02/2006 - 02/2005
2	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 03/2005 - 01/2004
1	Pyruvate Dehydrogenase Acetyl-Transferring KinaseIBA 02/2022
1	Lactic Acid (Lactate)FDA LinkGeneric 02/2022
1	Pyruvic Acid (Pyruvate)IBA 02/2022
1	CollagenIBA 01/2022
1	Indicators and Reagents (Reagents)IBA 01/2022
1	4-guanidinobenzoateIBA 01/2022
1	Biological ProductsIBA 01/2022
1	EstersIBA 01/2022
1	Adenosine Triphosphate (ATP)IBA 11/2021
1	Coenzyme A (CoA)IBA 11/2021
1	Triglycerides (Triacylglycerol)IBA 11/2021
1	Type 4 Melanocortin Receptor (Melanocortin-4 Receptor)IBA 11/2021
1	Acetyl-CoA CarboxylaseIBA 11/2021
1	CoagulantsIBA 09/2021
1	Warfarin (Coumadin)FDA LinkGeneric 09/2021
1	AnticoagulantsIBA 09/2021
1	Methionine (L-Methionine)FDA Link 01/2021
1	Immunoglobulin A (IgA)IBA 01/2021
1	Cysteine (L-Cysteine)FDA Link 01/2021
1	Serine Proteases (Serine Protease)IBA 01/2021
1	Appetite Depressants (Anorectics)IBA 01/2021
1	Choline (Choline Chloride)IBA 10/2020
1	Amino Acids FDA Link 10/2020
1	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2020
1	dapagliflozinIBA 10/2020
1	alogliptinIBA 10/2020
1	Neuromuscular Blocking AgentsIBA 12/2019
1	Rocuronium (Zemuron)FDA LinkGeneric 12/2019

Therapy/Procedure

5	Gastrectomy 07/2012 - 01/2007
3	Therapeutics 09/2017 - 06/2007
3	Laparoscopic Cholecystectomy 01/2015 - 01/2004
3	Epidural Anesthesia 02/2014 - 01/2004
2	Laparotomy 01/2022 - 01/2011
2	Oral Administration 01/2022 - 11/2017
2	Glycemic Control 10/2021 - 01/2019
2	Blood Transfusion (Blood Transfusions) 09/2021 - 06/2014
2	Catheters 01/2020 - 07/2003
2	Pancreaticoduodenectomy 01/2017 - 07/2012
2	Conservative Treatment 01/2017 - 02/2007
2	Length of Stay 01/2017 - 02/2008
2	Operative Surgical Procedures 06/2014 - 01/2013
2	Pancreatectomy 07/2012 - 01/2009
2	Colectomy 07/2012 - 08/2010
2	Lymph Node Excision (Lymph Node Dissection) 11/2010 - 01/2007
2	Analgesia 09/2008 - 01/2004
2	General Anesthesia 02/2007 - 01/2004
1	Aftercare (After-Treatment) 01/2022
1	Parenteral Nutrition 01/2020
1	Perioperative Period 12/2019